NANOTECH LAB | YUSHIN GROUP

Transforming the energy materials landscape from the nanoscale to the macro

Our research group focuses on finding nanotechnology-driven solutions to enable the next generation of lighter, more energy dense, more cost effective energy storage devices by studying their materials structure-property relationships. We have developed nano-scale synthesis strategies to bypass macro-scale limitations of energy and structural materials with applications in clean tech, electric vehicles, wearable electronics, and more.

Publications

Aluminum oxide nanowires as safe and effective adjuvants for next-generation vaccines

2018

Materials Today

R Bilyy, S Paryzhak, K Turcheniuk, T Dumych, A Barras, R Boukherroub, F Wang, G Yushin, S Szunerits

Improving efficiency of an adjuvant, material that enhances the body’s immune response to an antigen, has become vital for the development of safer, cheaper, and more effective next-generation vaccines. Commercial vaccines typically use aluminum salt-based adjuvant particles, most commonly aluminum oxyhydroxide (AlOOH) and aluminum hydroxide (Al(OH)3) based, often referred to as “alum”. Despite their broad use, their adjuvant properties are rather moderate. This is even worse in the case of aluminum oxide (Al2O3)-based adjuvant. While being more robust and less cytotoxic, Al2O3 is a significantly less effective adjuvant than above-mentioned Al compounds and is consequently not commonly used. Here, we report on the remarkably enhanced adjuvant properties of Al2O3 when produced in the form of nanowires (NWs). Based on recent advances in understanding neutrophil activation by inert nanoscaffolds, we have created ultra-long Al2O3 NWs with a high aspect ratio of ∼1000. These NWs showed strong humoral immune response with no damaging effect on the microvasculature. Since only the change of shape of Al adjuvants is responsible for the excellent adjuvant properties, our finding holds great promise for rapid implementation as safer and more effective adjuvant alternative for human vaccines. The mechanism behind human blood-derived neutrophil activation with Al2O3 NWs was found to be sequestering of Al2O3 NWs by neutrophils via formation of neutrophil extracellular traps (NETs).

Mechanisms of Transformation of Bulk Aluminum–Lithium Alloys to Aluminum Metal–Organic Nanowires

2018

Journal of the American Chemical Society

F Wang, K Turcheniuk, B Wang, AY Song, X Ren, A Vallamattam, A Park, K Hanley, T Zhu, G Yushin

Fabrication and applications of lightweight, high load-bearing, thermally stable composite materials would benefit greatly from leveraging the high mechanical strength of ceramic nanowires (NWs) over conventional particles or micrometer-scale fibers. However, conventional synthesis routes to produce NWs are rather expensive. Recently we discovered a novel method to directly convert certain bulk bimetallic alloys to metal–organic NWs at ambient temperature and pressure. This method was demonstrated by a facile transformation of polycrystalline aluminum–lithium (AlLi) alloy particles to aluminum alkoxide NWs, which can be further transformed to mechanically robust aluminum oxide (Al2O3) NWs. However, the transformation mechanisms have not been clearly understood. Here, we conducted advanced materials characterization (via electron microscopy and nuclear magnetic resonance spectroscopies) and chemo-mechanical modeling to elucidate key physical and chemical mechanisms responsible for NWs formation. We further demonstrated that the content of Li metal in the AlLi alloy could be reduced to about 4 wt % without compromising the success of the NWs synthesis. This new mechanistic understanding may open new avenues for large-scale, low-cost manufacturing of NWs and nanofibers for a broad range of composites and flexible ceramic membranes.

Collaborators

Some of the Institutions we’ve collaborated in the past. For collaboration inquiries, contact Professor Gleb Yushin.

Central South University
Xavier University of Louisiana
Technische Universität Dresden
Spanish National Research Council

Contact Us

Get in touch! Send an email to Professor Yushin at yushin@gatech.edu.